Quinolines and derivatives

Apexbio Technology LLC [Ser25] Protein Kinase C (19-31) 136795-05-6 5mg

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[Ser25] Protein Kinase C (19-31) (CAS 136795-05-6) is an oligopeptide derived from the pseudosubstrate regulatory domain (amino acids 19-31) of Protein Kinase C alpha (PKC ) modified by substitution of alanine with serine at residue 25 Its sequence is Arg-Phe-Ala-Arg-Lys-Gly-Ser-Leu-Arg-Gln-Lys-Asn-Val with a molecular weight of 1559 82 and molecular formula C67H118N26O17 It acts as a PKC substrate peptide enabling in vitro measurement of kinase enzymatic activity via serine phosphorylation PKC enzymes participate in diverse cellular processes including adhesion transformation cell cycle control and calcium signaling making this peptide an important tool for kinase activity studies and intracellular signaling research

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Apexbio Technology LLC Regorafenib 755037-03-7 200mg

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Regorafenib (CAS 755037-03-7) is an orally bioavailable inhibitor targeting multiple receptor tyrosine kinases (RTKs) such as VEGFR1/2/3 PDGFR Kit RET Raf-1 B-RAF and B-RAFV600E By impeding kinase phosphorylation (IC50 values ranging from approximately 1 5 46 nM) regorafenib disrupts signaling pathways associated with angiogenesis tumor cell proliferation and metastasis Preclinically regorafenib inhibited VEGFR2 phosphorylation (IC50 3 nM) and reduced VEGF-induced endothelial cell proliferation in vitro In rodent tumor xenograft models it demonstrated dose-dependent tumor growth suppression and antimetastatic potential supporting its utility for oncology research

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Apexbio Technology LLC LY2940680 1258861-20-9 200mg

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LY2940680 (CAS 1258861-20-9) is a selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane G protein-coupled receptor involved in regulating Hedgehog (Hh) signalling LY2940680 binds primarily to the extracellular loops of Smo distinguishing it from previously described inhibitors such as SANT-1 which bind to the transmembrane domain By blocking Smo function LY2940680 suppresses downstream Hh pathway activation resulting in reduced cell proliferation observed in cell lines with Smo mutations or resistance to vismodegib Investigations of LY2940680 in basal cell carcinoma and medulloblastoma highlight its potential utility as a single-agent therapeutic targeting cancer stem cell populations

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Apexbio Technology LLC Q-VD-OPh 1135695-98-5 25mg

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Q-VD-OPh is a pan-caspase inhibitor targeting caspases including 1 3 8 and 9 with IC50 values ranging from approximately 25 to 400 nM By blocking multiple caspase-mediated apoptotic pathways including caspase-9/3 caspase-8/10 and caspase-12 pathways Q-VD-OPh prevents apoptotic cell death induced by agents such as actinomycin D In research contexts this inhibitor serves as a tool to investigate apoptosis mechanisms across diverse cell types and species including human mouse and rat It is also used to enhance cell viability upon thawing from cryopreservation under standard cryoprotectant conditions

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Medchemexpress LLC 5(6)-Carboxy-2',7'-dichlorofluorescein | 111843-78-8 | 99.0% | 100 MG

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5(6)-Carboxy-2',7'-dichlorofluorescein is an ideal substrate for MRP2 vesicular transport assay, possessing excellent detection and transport properties.

• Ideal substrate for MRP2 vesicular transport assay
• Excellent detection and transport properties

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Ambeed 5Methoxy2nitrobenzaldehyde

5-Methoxy-2-nitrobenzaldehyde, 20357-24-8, 98%

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Ambeed AMBEED